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Ancestry-Stratified Transcriptome-Wide Association Study Reveals Tissue-Specific Mechanisms of Type 2 Diabetes Heterogeneity

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Type 2 diabetes (T2D) is a heterogeneous disease with clear differences in prevalence, pathophysiology, and treatment response across ancestral groups. To investigate transcriptomic mechanisms that may underlie this variation, ancestry-stratified transcriptome-wide association studies were performed with S-PrediXcan using summary statistics from the multi-ancestry T2D genome-wide associ...

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Literature Corpus work: d152bc9d-83bc-5d91-be65-605b528b45ff
DOI: 10.21203/rs.3.rs-9461073/v1

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