Article

Common genetic determinants of dynamic human in vivo immune response to <i>Mycobacterium tuberculosis</i>

2026-07-09

Abstract excerpt

We investigated host-genetic TB susceptibility by expression quantitative trait loci (eQTL) analysis of the tuberculin skin test (TST) as a standardised challenge model of human in vivo TB immunology. Paired genotyping with 415 RNA-sequencing profiles from day 2 and day 7 TST biopsies in 267 individuals with latent or active TB identified cis-eQTLs affecting 1,719 response genes. The strongest signal mapped to E...

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Literature Corpus work: 7e6e7b78-b477-5619-9e4a-3b2cb141dcc1
DOI: 10.64898/2026.07.06.26357408

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