Article
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity - 11 Jan 2022
Sugiura Ayaka, Andrejeva Gabriela, Voss Kelsey, Heintzman Darren R, Xu Xincheng, Madden Matthew Z, Ye Xiang, Beier Katherine L, Chowdhury Nowrin U, Wolf Melissa M, Young Arissa C, Greenwood Dalton L, Sewell Allison E, Shahi Shailesh K, Freedman Samantha N, Cameron Alanna M, Foerch Patrik, Bourne Tim, Garcia-Canaveras Juan C, Karijolich John, Newcomb Dawn C, Mangalam Ashutosh K, Rabinowitz Joshua D, Rathmell Jeffrey C
Abstract excerpt
Antigenic stimulation promotes T cell metabolic reprogramming to meet increased biosynthetic, bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulates de novo purine synthesis and signaling in activated T cells to promote proliferation and inflammatory cytokine production. In pathogenic T helper-17 (Th17) cells, MTHFD2...
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