Article

Structural elements required for the efficient loading and activation of HELB on RPA-coated single-stranded DNA

2026-07-17

Abstract excerpt

<h4>ABSTRACT</h4> HELB is a human helicase involved in DNA repair and replication that interacts physically with the single-stranded DNA binding protein RPA. ATP-dependent translocation of HELB along ssDNA results in the active displacement of RPA molecules and the formation of ssDNA loops, suggesting that HELB contains at least two DNA binding sites. In this work, we investigated the role of HELB-specific struct...

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Literature Corpus work: 52dbc7ad-8703-5c65-93ad-37774054ccd5
DOI: 10.64898/2026.07.16.738708

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