Article
Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.
PloS one - 27 Aug 2009
Oakley Miranda S, Majam Victoria, Mahajan Babita, Gerald Noel, Anantharaman Vivek, Ward Jerrold M, Faucette Lawrence J, McCutchan Thomas F, Zheng Hong, Terabe Masaki, Berzofsky Jay A, Aravind L, Kumar Sanjai
Abstract excerpt
An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM ) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has...
Topics
- Animals
- Blotting, Western
- Female
- Flow Cytometry
- Galectin 3
- Lipopolysaccharide Receptors
- Malaria, Cerebral
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Polymorphism, Single Nucleotide
- Receptors, OX40