Article

Deletion of OTUD7B in astrocytes protects against cerebral malaria by inhibiting microvesicle-induced TRAF3/TRAF6-mediated neuroinflammation

2026-04-21

Abstract excerpt

Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection. Damage of the blood-brain barrier (BBB) and endothelial dysfunction are established drivers of the disease pathology, however, whether astrocytes, a major constituent of the BBB, influence the disease outcome remains unclear. Using the murine model of experimental cerebral malaria (ECM), we show that astrocytes decisively r...

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Literature Corpus work: 4d864925-0249-5029-9782-fba11dabdf82
DOI: 10.64898/2026.04.16.717638

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