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Article

Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria

11 Jul 2013

Abstract excerpt

Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells. BXH2 mice harbor a severely hypomorphic allele at Irf8 (Irf8(R294C)) that causes susceptibility to infection with intracellular pathogens including Mycobacterium tuberculosis. We report that BXH2 are completely resistant to the development of cerebral malaria (ECM) following...

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PMID: 23853600
DOI: 10.1371/journal.ppat.1003491

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