Article

Therapeutic inhibition of glycolysis preferentially targets pathogenic monocyte subsets and attenuates CNS inflammation in flavivirus encephalitis

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Infiltrating monocytes play a dual role in central nervous system (CNS) diseases, both driving and attenuating inflammation. However, it is unclear how metabolic pathways preferentially fuel protective or pathogenic processes and whether these can be therapeutically targeted to enhance or inhibit these opposing functions. Here, we employed single-cell RNA-sequencing and metabolic protei...

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Literature Corpus work: 2338d794-67f5-59ed-911b-940a89b188cf
DOI: 10.21203/rs.3.rs-4018869/v1

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