Article

Emergence of directional bias in tau deposition from axonal transport dynamics

2021-03-22

Abstract excerpt

Defects in axonal transport may partly underpin the differences between the observed pathophysiology of Alzheimer’s disease (AD) and that of other non-amyloidogenic tauopathies. Particularly, pathological tau variants may have molecular properties that dysregulate motor proteins responsible for the anterograde-directed transport of tau in a disease-specific fashion. Here we develop the first computational model of...

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Literature Corpus work: fc544546-fa31-5dd0-bcd6-e82e8bcb119d
DOI: 10.1101/2021.03.22.436470

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