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Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

28 Mar 2018

Abstract excerpt

The ordered assembly of amyloidogenic proteins causes a wide spectrum of common neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. These diseases share common features with prion diseases, in which misfolded proteins can self-replicate and transmit disease across different hosts. Deciphering the molecular mechanisms that underlie the amplification of aggregates is fundamental for...

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PMID: 29590529
DOI: 10.1021/acschemneuro.8b00094

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