Article

ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice

2025-01-14

Abstract excerpt

<h4>Background</h4> Intracranial aneurysm (IA) is a common cerebrovascular abnormality characterized by localized dilation and wall thinning in intracranial arteries, that frequently leads to fatal sub-arachnoid hemorrhage. Pathophysiological mechanisms responsible for AI remains largely unknown, but increasing evidence suggest that genetic susceptibility plays a predominant role. We recently identified a rare no...

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Literature Corpus work: 8885faf5-1db0-5ffd-8741-566eacde56ab
DOI: 10.1101/2025.01.10.632391

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