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Article

RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease.

Molecular neurobiology - 1 Oct 2025

Shen Juan, Wang Yue, Qin Yuchen, Chen Gan, Xu Jun, Li Yunzhu, Hou Yaru, Liu Yanling, Liu Wanyang

Abstract excerpt

Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease. Ring finger protein 213 (RNF213) is a susceptibility gene for MMD. Numerous studies have highlighted that RNF213 regulates angiogenesis; its precise regulatory role and mechanism remain controversial. Moreover, the impacts and mechanisms of RNF213 on vascular smooth muscle cell (VSMC) phenotype switching are also rarely reported. Inflammation...

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Identifiers

PMID: 40467938
DOI: 10.1007/s12035-025-05103-0

Genes

RNF213
JAK2
STAT3
MMD

Provenance

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