KRIT1 in vascular biology and beyond.

Abstract excerpt

KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting the response to inflammatory stimuli and maintaining a quiescent and stable endothelial barrier. Loss-of-function mutations in KRIT1 lead to the development of cerebral cavernous malformations (CCM), a di...

Topics

• Humans
• KRIT1 Protein
• Hemangioma, Cavernous, Central Nervous System
• Animals
• Endothelial Cells
• Apoptosis Regulatory Proteins
• Mutation