Article
Reck enables cerebrovascular development by promoting canonical Wnt signaling.
Development (Cambridge, England) - 1 Jan 2016
Ulrich Florian, Carretero-Ortega Jorge, Menéndez Javier, Narvaez Carlos, Sun Belinda, Lancaster Eva, Pershad Valerie, Trzaska Sean, Véliz Evelyn, Kamei Makoto, Prendergast Andrew, Kidd Kameha R, Shaw Kenna M, Castranova Daniel A, Pham Van N, Lo Brigid D, Martin Benjamin L, Raible David W, Weinstein Brant M, Torres-Vázquez Jesús
Abstract excerpt
The cerebral vasculature provides the massive blood supply that the brain needs to grow and survive. By acquiring distinctive cellular and molecular characteristics it becomes the blood-brain barrier (BBB), a selectively permeable and protective interface between the brain and the peripheral circulation that maintains the extracellular milieu permissive for neuronal activity. Accordingly, there is great interest...
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