Article
DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2018
Karamariti Eirini, Zhai Chungang, Yu Baoqi, Qiao Lei, Wang Zhihong, Potter Claire M F, Wong Mei Mei, Simpson Russell M L, Zhang Zhongyi, Wang Xiaocong, Del Barco Barrantes Ivan, Niehrs Christof, Kong Deling, Zhao Qiang, Zhang Yun, Hu Yanhua, Zhang Cheng, Xu Qingbo
Abstract excerpt
OBJECTIVE: DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in vascular disease. This study aims to assess the effects of DKK3 on atherosclerotic plaque composition. APPROACH AND RESULTS: In the present study, we used a murine model...
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