Article

Elastase mediated white matter damage in cerebral small vessel disease: Microglia - neutrophils pas de deux

2024-12-24

Abstract excerpt

<h4>SUMMARY</h4> Cerebral small vessel disease (CSVD) leads to an extensive white matter damage associated with cognitive decline, yet the underlying damaging mechanisms remain incompletely understood. Here we established a positive correlation between plasma levels of serine proteinase elastase ELANE and periventricular white matter hyperintensity (PV-WMH) in a cohort of CSVD patients. In a CSVD murine model ind...

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Literature Corpus work: b2133f09-8a41-5024-b4e0-fbc7d8ba5ade
DOI: 10.1101/2024.12.23.630204

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