Article

Pericytes from individuals with multiple sclerosis show reduced contractility but remain responsive to myelin debris, hypoxia, and inflammatory cytokines

2025-07-17

Abstract excerpt

Multiple sclerosis (MS) is a complex inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS), that is accompanied by vascular abnormalities such as cerebral hypoperfusion, neurovascular uncoupling, and blood–brain-barrier (BBB) disruption. Pericytes regulate cerebral blood flow at capillaries and maintain the BBB and pericyte dysfunction may play a role in MS pathogenesis. By...

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Literature Corpus work: fc225933-4258-59dd-b659-80cd1f3999f5
DOI: 10.1101/2025.07.15.25331537

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