Article

Early endothelial activation at the blood–nerve barrier defines a hallmark of ALS

2025-09-04

Abstract excerpt

<h4>ABSTRACT</h4> Vascular defects are common in Amyotrophic Lateral Sclerosis (ALS). The prevailing view is that breakdown of the blood–brain and blood–spinal cord barriers contributes to neurodegeneration. Here, we reveal that selective and early vulnerability of peripheral nerve endothelium —manifested as endothelial cell activation and interlinked blood–nerve barrier dysfunction— constitutes a core feature of...

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Identifiers and source

Literature Corpus work: 7bb0139b-f020-5d2f-bf93-186fcd3eb54d
DOI: 10.1101/2025.08.31.673224

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