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Increased plasma fibronectin mirrors intimal phenotypic switching of vascular smooth muscle cells in moyamoya arteriopathy

2025-10-03

Abstract excerpt

Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive stenosis of large intracranial arteries and formation of fragile collateral vessels that can be triggered by a broad range of genetic and immune factors. Central to MMD pathology is excessive proliferation of vascular smooth muscle cells (VSMCs) in the intima of affected arteries associated with contractile-to-synthetic phenotyp...

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Literature Corpus work
0b0be250-76b7-5577-93d0-d171c5f35f3e
DOI
10.1101/2025.09.26.25336314
Open publication

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