Article

Amyloid ß<sub>1–42</sub> Peptide Induces Galectin-1<sup>S8</sup> O-GlcNAcylation to Lead Microglia Migration

2023-05-18

Abstract excerpt

Protein O-GlcNAcylation has been associated with neurodegenerative diseases such as Alzheimer´s disease (AD). O-GlcNAcylation of Amyloid Precursor Protein (APP) regulates both the trafficking and the processing of the APP through the amyloidogenic pathway, resulting in the release and aggregation of the Aβ1-42 peptide. Microglia clear Aβ aggregates and dead cells to maintain brain homeostasis. Here, using LC-MS/MS...

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Literature Corpus work: 2ccdb761-8ff7-5929-a9f9-6741b997b59f
DOI: 10.20944/preprints202305.1347.v1

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