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Article

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

2019-12-02

Abstract excerpt

Microglial dysfunction is a key pathological feature of Alzheimeŕs disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their functional consequences. Here, we performed an in-depth and time-resolved proteomic characterization of microglia in two mouse models of amyloid β (Aβ) pathology, the overexpression APPPS1 and the knock-in APP-NL-G-F (APP-KI) mo...

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Literature Corpus work
2a1d1774-207b-536b-be1c-e08f9421d82e
DOI
10.1101/861146
Open publication

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Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse modelsDOI 10.1101/861146
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