Article

Mast cell-derived BH4 is a critical mediator of postoperative pain

2023-01-24

Abstract excerpt

Postoperative pain affects most patients after major surgery and can transition to chronic pain. Here, we discovered that postoperative pain hypersensitivity correlated with markedly increased local levels of the metabolite BH4. Gene transcription and reporter mouse analyses after skin injury identified neutrophils, macrophages and mast cells as primary postoperative sources of GTP cyclohydrolase-1 ( Gch1 ) expre...

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Literature Corpus work: fc1b561f-663c-5081-801a-a70daec9feea
DOI: 10.1101/2023.01.24.525378

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