Article

IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells

2023-03-10

Abstract excerpt

<title>Abstract</title> <p>Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy in disease settings through orchestrating inflammatory microenvironments. Nevertheless, the mechanisms underlying the immunoregulatory property of MuSCs remain largely uncharacterized. Here, we showed that interleukin-4-induced-1 (IL4I1), an essential enzyme that catalyzes indole metabolism in huma...

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Literature Corpus work: b897ac41-794f-5584-b0d5-9db53ea5f1a9
DOI: 10.21203/rs.3.rs-2618290/v1

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