Article

Substance P, mast cells and basophils are involved in acute chest syndrome in sickle cell disease

2026-03-03

Abstract excerpt

A role for substance P in promoting neurogenic inflammation and pain has been described in sickle cell disease (SCD). However its origin and contribution to SCD pathophysiology remain unclear. We measured substance P level in plasma from 225 patients with SCD and observed the highest concentrations during acute chest syndrome (ACS). Therefore, we tested the hypothesis that substance P may induce ACS. In transgenic...

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Literature Corpus work: fa0d3e24-435c-50c3-aa8c-cdacdd56084d
DOI: 10.64898/2026.03.02.26347450

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