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Article

Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models

24 Oct 2024

Abstract excerpt

Bone cancer pain (BCP) affects ~70% of patients in advanced stages, primarily due to bone metastasis, presenting a substantial therapeutic challenge. Here, we profile orphan G protein-coupled receptors in the dorsal root ganglia (DRG) following tumor infiltration, and observe a notable increase in GPR160 expression. Elevated Gpr160 mRNA and protein levels persist from postoperative day 6 for over 18 days in the...

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PMID: 39448865
DOI: 10.1038/s44319-024-00292-6

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