Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.

doi:10.1016/j.bja.2024.04.053

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Article

Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.

British journal of anaesthesia - 1 Aug 2024

Parisien Marc, van Reij Roel R I, Khoury Samar, Koseli Eda, Karaky Mohamad, Silva Jaqueline R, Taheri Golnar, van den Hoogen Nynke J, Peng Garrie, Allegri Massimo, De Gregori Manuela, Chelly Jacques E, Rakel Barbara A, Aasvang Eske K, Kehlet Henrik, Buhre Wolfgang F F A, Bryant Camron D, Damaj M Imad, King Irah L, Ghasemlou Nader, Mogil Jeffrey S, Joosten Elbert A J, Diatchenko Luda

Abstract excerpt

BACKGROUND: Chronic post-surgical pain (CPSP) significantly impacts patients' recovery and quality of life. Although environmental risk factors are well-established, genetic risk remains less understood. METHODS: A meta-analysis of genome-wide association studies followed by partitioned heritability was performed on 1350 individuals across five surgery types: hysterectomy, mastectomy, abdominal, hernia, and knee....

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Identifiers

PMID: 38862382
DOI: 10.1016/j.bja.2024.04.053
PMCID: PMC11282472

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