Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of a role for GTP cyclohydrolase-1 in visceral pain.

Neurogastroenterology and motility - 1 May 2015

Bulmer D C, Botha C A, Wheeldon A, Grey K, Mein C A, Lee K, Knowles C H, Winchester W J, Aziz Q

Abstract excerpt

BACKGROUND: The enzyme guanosine triphosphate-cyclohydrolase-1 (GCH-1) is a rate limiting step in the de novo synthesis of tetrahydrobiopterin (BH4) a co-factor in monoamine synthesis and nitric oxide production. GCH-1 is strongly implicated in chronic pain based on data generated using the selective GCH-1 inhibitor 2,4-diamino-6-hydroxypyrimidine (DAHP), and studies which have identified a pain protective GCH-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Over Studies
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Esophagus

Share to GTP Cyclohydrolase

Share to Mustard Plant

Share to Plant Oils

Share to Protective Factors

Share to Rectum

Source

Identifiers

PMID: 25783971
DOI: 10.1111/nmo.12538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of a role for GTP cyclohydrolase-1 in visceral pain.PMID 25783971Read ↗

Mast cell-derived BH4 is a critical mediator of postoperative painSemantic proximity Read ↗

A GTP cyclohydrolase 1 genetic variant delays cancer pain.Semantic proximity Read ↗

Polymorphisms in the GTP cyclohydrolase gene ( GCH1 ) are associated with ratings of capsaicin painSemantic proximity Read ↗

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.Semantic proximity Read ↗

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.Semantic proximity Read ↗

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.Semantic proximity Read ↗

GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases.Semantic proximity Read ↗

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.Semantic proximity Read ↗

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?Semantic proximity Read ↗

Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.Semantic proximity Read ↗

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.Semantic proximity Read ↗

Effective Relief of Neuropathic Pain by Adeno-Associated Virus-Mediated Expression of a Small Hairpin Rna against GTP Cyclohydrolase 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.