Article

Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humans

2022-03-08

Abstract excerpt

Pain after surgery is common, and its management remains a clinical challenge. Severe acute and prolonged post-surgical pain impairs immediate recovery and leads to long-term consequences like chronic pain, opioid dependency, and reduced quality of life. Althought rodent pain incision models exist, translation to patients is still hampered. To bridge this gap, we combined sensory phenotyping with quantitative prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bfe8186-82f7-589b-aa09-d652259c17ca
DOI: 10.1101/2022.03.07.482980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humansDOI 10.1101/2022.03.07.482980Read

BLOOD PROTEOMICS AND PAIN - A TRANSLATIONAL STUDY TO PROGNOSTICATE PAIN PHENOTYPES AND ASSESS NEW BIOMARKERS FOR PREVENTING PAIN IN HUMANSSemantic proximity Read

Deep Proteome Profiling Reveals Signatures of Age and Sex Differences in Paw Skin and Sciatic Nerve of Naïve MiceSemantic proximity Read

Subtype-Resolved Pain-Signaling Architectures Reveal Conserved Drug-Target Interaction Networks in DRG NociceptorsSemantic proximity Read

Nociceptor-immune interactomes reveal insult-specific immune signatures of painSemantic proximity Read

Sensory, cytokine and metabolic profiling of human experimental burn injury pain modelsSemantic proximity Read

Network proteomics of human dermal wound healingSemantic proximity Read

Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic PainSemantic proximity Read

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic painSemantic proximity Read

Plantar Skin Exhibits Altered Physiology, Constitutive Activation of Wound-Associated Phenotypes, and Inherently Delayed Healing.Semantic proximity Read

The pain interactome: Connecting pain-specific protein interactionsSemantic proximity Read

Robust classification of wound healing stages in both mice and humans for acute and burn wounds based on transcriptomic dataSemantic proximity Read

ADVANTAGE: Advanced discovery of visceral analgesics by neuroimmune targets and the genetics of extreme human phenotype, a study protocol.Semantic proximity Read