Article

Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region

2023-05-04

Abstract excerpt

<title>Abstract</title> <p>The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and addiction associated with opioids, nephrotoxicity, and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use, as well as acute liver injury from paracetamol (ApAP) overdose, are unresolved challenges. To address them, we developed a non-opioi...

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Literature Corpus work: ac1ff848-f530-58cd-bb58-45f930c947d6
DOI: 10.21203/rs.3.rs-2883310/v1

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Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG regionDOI 10.21203/rs.3.rs-2883310/v1Read

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