Article

Combined PD-L1 and TIM-3 blockade improves the expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy

2021-09-02

Abstract excerpt

<h4>Background</h4> The stimulation and expansion of antigen-specific T cells ex vivo enables the targeting of a multitude of cancer antigens. However, clinical scale T-cell expansion from rare precursors requires repeated stimulations ex vivo leading to T-cell terminal effector differentiation and exhaustion that adversely impact therapeutic potential. We leveraged immune checkpoint blockade relevant to antigen-s...

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Literature Corpus work: fc1a71fa-801d-556f-9e09-c5ff3768d0fc
DOI: 10.1101/2021.08.30.21262835

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