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Article

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.

Journal of translational medicine - 9 Aug 2011

Ye Qunrui, Loisiou Maria, Levine Bruce L, Suhoski Megan M, Riley James L, June Carl H, Coukos George, Powell Daniel J

Abstract excerpt

BACKGROUND: Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL numbers or tumor tissues challenges their clinical application. METHODS: To facilitate adoptive immunotherapy, we applied genetically-engineered K562 cell-based artificial antigen presenting cells (aAPCs) for the direct and rapid expansion of...

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Source

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Identifiers

PMID: 21827675
DOI: 10.1186/1479-5876-9-131
PMCID: PMC3162913

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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