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Article

A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse.

Neuron - 2 May 2018

Keum Sehoon, Kim Arie, Shin Jae Jin, Kim Jong-Hyun, Park Joomin, Shin Hee-Sup

Abstract excerpt

Empathy is crucial for our emotional experience and social interactions, and its abnormalities manifest in various psychiatric disorders. Observational fear is a useful behavioral paradigm for assessing affective empathy in rodents. However, specific genes that regulate observational fear remain unknown. Here we showed that 129S1/SvImJ mice carrying a unique missense variant in neurexin 3 (Nrxn3) exhibited a...

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PMID: 29681532
DOI: 10.1016/j.neuron.2018.03.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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