Article

15-Lipoxygenase-Mediated Lipid Peroxidation Regulates LRRK2 Kinase Activity

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in leucine-rich repeat kinase 2 (LRRK2) that increase its kinase activity are strongly linked to genetic forms of Parkinson’s disease (PD). However, the regulation of endogenous wild-type (WT) LRRK2 kinase activity remains poorly understood, despite its frequent elevation in idiopathic PD (iPD) patients. Various stressors such as mitochondrial dysfunction, lysosomal dyshomeostasis, or...

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Literature Corpus work: fc149c03-d699-56e8-810d-df1fabef651b
DOI: 10.1101/2024.06.12.598654

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