Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway.

Neurobiology of disease - 1 Oct 2008

Liou Anthony K F, Leak Rehana K, Li Lihua, Zigmond Michael J

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a recently identified gene that, when mutated at specific locations, results in the onset of parkinsonian symptoms with clinical features indistinguishable from idiopathic Parkinson's disease. Based on structural and domain analysis, LRRK2 is predicted to function as a stress-responsive protein scaffold mediating the regulation of mitogen activating protein kinase (MAPK)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cell Line, Tumor
Share to Cell Survival

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to MAP Kinase Signaling System

Share to Oxidative Stress

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 18675914
DOI: 10.1016/j.nbd.2008.06.016
PMCID: PMC2580823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway.PMID 18675914Read ↗

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.Semantic proximity Read ↗

Cellular processes associated with LRRK2 function and dysfunction.Semantic proximity Read ↗

LRRK2 and idiopathic Parkinson's disease.Semantic proximity Read ↗

The biology and pathology of the familial Parkinson's disease protein LRRK2.Semantic proximity Read ↗

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model.Semantic proximity Read ↗

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neuronsSemantic proximity Read ↗

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.Semantic proximity Read ↗

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.Semantic proximity Read ↗

LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease.Semantic proximity Read ↗

LRRK2 in Parkinson's disease: function in cells and neurodegeneration.Semantic proximity Read ↗

LRRK2 Phosphorylation: Behind the Scenes.Semantic proximity Read ↗

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.