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Article

LRRK2 and Lipid Pathways: Implications for Parkinson's Disease.

Biomolecules - 30 Oct 2022

Galper Jasmin, Kim Woojin S, Dzamko Nicolas

Abstract excerpt

Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a common risk factor for Parkinson's disease. How LRRK2 alterations lead to cell pathology is an area of ongoing investigation, however, multiple lines of evidence suggest a role for LRRK2 in lipid pathways. It is increasingly recognized that in addition to being energy reservoirs and structural entities, some lipids, including...

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Identifiers

PMID: 36358947
DOI: 10.3390/biom12111597
PMCID: PMC9687231

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