Article

An <i>N</i> -acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson’s disease

2026-03-21

Abstract excerpt

N -acylphosphatidylethanolamines (NAPEs) are atypical glycerophospholipids that accumulate in response to cellular stress, yet their roles beyond serving as precursors of fatty-acid ethanolamines (FAEs) remain largely unexplored. Here, we identify NAPEs as endogenous regulators of leucine-rich repeat kinase 2 (LRRK2), a master controller of lysosomal homeostasis and a genetic driver of Parkinson’s disease. We show...

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Literature Corpus work: 1819f536-a4de-5dce-88d1-1d2efd952a2d
DOI: 10.64898/2026.03.19.712902

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