LRRK2 and idiopathic Parkinson's disease.

doi:10.1016/j.tins.2021.12.002

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Article

LRRK2 and idiopathic Parkinson's disease.

Trends in neurosciences - 1 Mar 2022

Rocha Emily M, Keeney Matthew T, Di Maio Roberto, De Miranda Briana R, Greenamyre J Timothy

Abstract excerpt

The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 (LRRK2) that are associated with increased kinase activity are the most common cause of autosomal dominant PD, the role of LRRK2 in iPD, independent of mutations, remains uncertain. In this review, we discuss how the architecture of...

Topics

Endosomes
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lysosomes
Mutation
Parkinson Disease
Phosphorylation

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Identifiers

PMID: 34991886
DOI: 10.1016/j.tins.2021.12.002
PMCID: PMC8854345

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