Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

doi:10.1002/humu.21582

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Article

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.

Human mutation - 1 Dec 2011

Angeles Dario C, Gan Bong-Hwa, Onstead Luisa, Zhao Yi, Lim Kah-Leong, Dachsel Justus, Melrose Heather, Farrer Matt, Wszolek Zbigniew K, Dickson Dennis W, Tan Eng-King

Abstract excerpt

Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are responsible for autosomal dominant and sporadic Parkinson disease (PD), possibly exerting their effects via a toxic gain of function. A common p.G2019S mutation (rs34637584:A>G) is responsible for up to 30-40% of PD cases in some ethnic populations. Here, we show that LRRK2 interacts with human peroxiredoxin 3 (PRDX3), a mitochondrial member of the...

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PMID: 21850687
DOI: 10.1002/humu.21582

Genes

PRDX3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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