Article

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer’s disease and uncovers adult lifespan memory decline

2023-10-12

Abstract excerpt

Across healthy adult life our brains undergo gradual structural change in a pattern of atrophy that resembles accelerated brain changes in Alzheimer’s disease (AD). Here, using four polygenic risk scores for AD (PRS-AD) in a longitudinal adult lifespan sample aged 30 to 89 years (2-7 timepoints), we show that healthy individuals who lose brain volume faster than expected for their age, have a higher genetic AD ris...

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Literature Corpus work: fc0107b1-06dc-5a38-a7f2-97f727d9a3df
DOI: 10.1101/2023.10.09.559446

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