Article

Sex Differences in the Alzheimer’s Brain Age Gap: APOE ε4 Plays a Major Role

2026-07-16

Abstract excerpt

<h4>INTRODUCTION</h4> Brain age gap (BAG) is the difference between a person’s chronological age and the age predicted from the structural appearance of their brain on MRI. A higher BAG indicates an older-appearing brain and provides a global marker of structural brain aging across the Alzheimer’s disease continuum. Prior studies suggest that females may show greater Alzheimer’s disease-related pathology or faste...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc6c08df-4588-5456-80b8-9a24e1cfc3fc
DOI: 10.64898/2026.07.13.26357678

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex Differences in the Alzheimer’s Brain Age Gap: APOE ε4 Plays a Major RoleDOI 10.64898/2026.07.13.26357678Read

Machine Learning-Driven Prediction of Brain Age for Alzheimer's Risk: APOE4 Genotype and Gender EffectsSemantic proximity Read

Regional brain aging patterns reveal disease-specific pathways of neurodegenerationSemantic proximity Read

Sex differences in brain aging among adults with family history of Alzheimer's disease and APOE4 genetic risk.Semantic proximity Read

Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measuresSemantic proximity Read

Mapping sex differences in brain and cognition in relation to<i>APOE4</i>and amyloid burden: A longitudinal normative modelling studySemantic proximity Read

Alzheimer’s Disease Brain Phenotypes are Age-dependentSemantic proximity Read

Mind the Gap: Does Brain Age Improve Alzheimer’s Disease Prediction?Semantic proximity Read

Genetic architecture of brain age and its casual relations with brain and mental disordersSemantic proximity Read

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer’s disease and uncovers adult lifespan memory declineSemantic proximity Read

Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based studySemantic proximity Read

Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohortSemantic proximity Read

Deep neural networks learn general and clinically relevant representations of the ageing brainSemantic proximity Read