Article

Regional brain aging patterns reveal disease-specific pathways of neurodegeneration

2025-11-14

Abstract excerpt

The heterogeneity of brain aging is a hallmark of neurological and psychiatric disorders, yet machine-learning tools used to characterize this process, including the ‘brain age’ paradigm, have largely relied on global metrics that lack the specificity to map these complex patterns. Here, we introduce BrainAgeMap, an interpretable deep learning framework that generates fine-grained, voxel-wise maps of brain-predict...

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Literature Corpus work: d704394b-59ec-5230-a755-4e4ed29850f3
DOI: 10.1101/2025.11.12.25339989

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