Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.

doi:10.1038/s41467-024-53548-z

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Article

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.

Nature communications - 17 Dec 2024

Roe James M, Vidal-Piñeiro Didac, Sørensen Øystein, Grydeland Håkon, Leonardsen Esten H, Iakunchykova Olena, Pan Mengyu, Mowinckel Athanasia, Strømstad Marie, Nawijn Laura, Milaneschi Yuri, Andersson Micael, Pudas Sara, Bråthen Anne Cecilie Sjøli, Kransberg Jonas, Falch Emilie Sogn, Øverbye Knut, Kievit Rogier A, Ebmeier Klaus P, Lindenberger Ulman, Ghisletta Paolo, Demnitz Naiara, Boraxbekk Carl-Johan, Drevon Christian A, Penninx Brenda, Bertram Lars, Nyberg Lars, Walhovd Kristine B, Fjell Anders M, Wang Yunpeng

Abstract excerpt

Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer's disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2-7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. We first show genetic risk links with more...

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PMID: 39690174
DOI: 10.1038/s41467-024-53548-z
PMCID: PMC11652687

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