Article

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

2023-01-20

Abstract excerpt

<h4>Background</h4> Mitochondrial dysfunction, characterized by impaired lipid metabolism and heightened reactive oxygen species (ROS) generation, results in lipid peroxidation and ferroptosis. Ferroptosis is an inflammatory mode of cell death that promotes complement activation and macrophage recruitment. In pulmonary arterial hypertension (PAH), pulmonary arterial endothelial cells (PAEC) exhibit cellular pheno...

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Literature Corpus work: 94cea7d5-2807-5249-aa05-0212a12e9d36
DOI: 10.1101/2023.01.19.524721

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