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Article

Baseline and Disease-Induced Transcriptional Profiles in Children with Sickle Cell Disease

2 Jun 2020

Abstract excerpt

Acute chest syndrome (ACS) is a significant cause of morbidity and mortality in sickle cell disease (SCD), but preventive, diagnostic, and therapeutic options are limited. Further, ACS and acute vasoccclusive pain crises (VOC) have overlapping features, which causes diagnostic dilemmas. We explored changes in gene expression profiles among patients with SCD hospitalized for VOC and ACS episodes to better...

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PMID: 32487996
DOI: 10.1038/s41598-020-65822-3

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