Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target

Abstract excerpt

Despite being the first genetic disease described, sickle cell disease (SCD) continues to result in severe complications. Of these complications, acute chest syndrome (ACS), a form of acute lung injury, leads all-cause mortality. However, the pathophysiology of ACS remains incompletely understood, resulting in patients with ACS receiving only supportive measures. Here, we found that ACS is accompanied by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood groups and transfusion
• Share to Erythrocyte Function and Pathophysiology
• Share to Hemoglobinopathies and Related Disorders