Article

Transcriptomic gene profiles in an ex vivo model of erythropoiesis to unravel molecular pathomechanisms of Sickle Cell Disease

2023-11-28

Abstract excerpt

We characterized the transcriptional profiles of erythroid cells differentiated from peripheral blood mononuclear cells (PBMCs) from peripheral blood collected from patients diagnosed with Sickle Cell Disease (SCD), which have been treated with Hydroxyurea (HU) in comparison to untreated SCD patients and healthy controls (HC) using bulk RNAseq. We identified 398 differentially expressed genes (DEGs) in SCD non-tre...

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Literature Corpus work: 18a4e7c0-a5a1-57d5-81ac-f01fa84bd271
DOI: 10.21203/rs.3.rs-3615607/v1

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