Article

Transcriptomic gene profiles in an <i>ex vivo</i> model of erythropoiesis to unravel molecular pathomechanisms of Sickle Cell Disease

2023-09-28

Abstract excerpt

We characterized the transcriptional profiles of erythroid cells differentiated from peripheral blood mononuclear cells (PBMCs) from peripheral blood collected from patients diagnosed with Sickle Cell Disease (SCD), which have been treated with Hydroxyurea (HU) in comparison to untreated SCD patients and healthy controls (HC) using bulk RNAseq. We identified 1398 differentially expressed genes (DEGs) in SCD non-tr...

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Literature Corpus work: f28b8cc1-9684-5e93-a497-3ad55fc6845b
DOI: 10.1101/2023.09.26.559266

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