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Article

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

2021-07-07

Abstract excerpt

<h4>ABSTRACT</h4> The roles of mitochondrial respiration in pluripotency remain largely unknown. We show here that mouse ESC mitochondria possess superior respiration capacity compared to somatic cell mitochondria, and oxidative phosphorylation (OXPHOS) generates the majority of cellular ATP in ESCs. Inhibition of OXPHOS results in extensive pluripotency and metabolic gene expression reprogram, leading to disrupt...

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Identifiers and source

Literature Corpus work
fbd1c3cb-d1d3-56ce-9d68-8b375634b6aa
DOI
10.1101/2021.07.06.451381
Open publication

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Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamineDOI 10.1101/2021.07.06.451381
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