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ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance

11 Aug 2016

Abstract excerpt

Pluripotent stem cells, including induced pluripotent and embryonic stem cells (ESCs), have less developed mitochondria than somatic cells and, therefore, rely more heavily on glycolysis for energy production.Citation1-3 However, how mitochondrial homeostasis matches the demands of nuclear reprogramming and regulates pluripotency in ESCs is largely unknown. Here, we identified ATG3-dependent autophagy as an...

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PMID: 27575019
DOI: 10.1080/15548627.2016.1212786

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