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Article

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.

Nature cell biology - 1 May 2017

Cha Young, Han Min-Joon, Cha Hyuk-Jin, Zoldan Janet, Burkart Alison, Jung Jin Hyuk, Jang Yongwoo, Kim Chun-Hyung, Jeong Ho-Chang, Kim Byung-Gyu, Langer Robert, Kahn C Ronald, Guarente Leonard, Kim Kwang-Soo

Abstract excerpt

A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the 'Warburg effect', which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is a molecular signature of primed hPSCs and that SIRT2 critically regulates metabolic reprogramming during induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28436968
DOI: 10.1038/ncb3517
PMCID: PMC5545746

Genes

SIRT2
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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